This story was updated to add new information.)

Another week, another injury to a Buffalo Bills defensive starter.

Buffalo lost former All-Pro linebacker Matt Milano to a torn biceps in training camp. All-Pro nickel back Taron Johnson went down with a forearm injury on the seventh play of the season. Linebacker Terrel Bernard, the Bills' leading tackler a year ago, exited with a pectoral strain in the first quarter in Week 2.

The Jacksonville Jaguars added injury to insult when tight end Evan Engram injured his hamstring in warmups and didn't play in their 18-13 loss Sunday to the Cleveland Browns. Running back Tank Bigsby was rocked on a second-quarter kickoff return, injured his shoulder, and did not play any snaps on offense.

The Bills get 10 days between games to recuperate before hosting the Jaguars on at 7:30 p.m. on Monday Night Football.

NFL teams have to submit a report on practice participation on Thursday, Friday and Saturday for a Monday game. There are three levels of practice participation that can be designated: did not participate, limited participation and full participation.

A game status report is due by 4 p.m. Saturday for Monday Night Football.

Here is the Bills vs. Jaguars injury report for Week 3:

Bills vs. Jaguars inactives

Here is who is not playing in the Bills vs. Jaguars game on Monday Night Football.

Bills: CB Taron Johnson, S Mike Edwards, LB Terrel Bernard, LB Edefuan Ulofoshio, OT Ryan Van Demark

Jaguars: S Darnell Savage, TE Evan Engram, DE Myles Cole, OL Javon Foster, OL Cole Van Lanen, DT Esezi Otomewo, DT Jordan Jefferson

Buffalo Bills injury update for Monday Night Football

Terrel Bernard, LB, pectoral

Terrel Bernard suffered a pectoral strain in the first quarter against the Miami Dolphins in Week 2. Bernard avoided a torn pectoral and season ending injury, and could miss about a month, according to Bills coach Sean McDermott.

McDermott said Wednesday that Bernard will not play against the Jaguars.

Status: Did not practice Thursday, Friday or Saturday; Out

Taron Johnson, CB, forearm

Taron Johnson was injured seven plays into Week 1 while attempting to tackle Cardinals' wide receiver Greg Dortch. Johnson didn't return to the game. He missed Week 2 against the Miami Dolphins. Head coach Sean McDermott didn't give a timetable for the starting nickel back's return but Johnson has not been placed on injured reserve, which would have required him to miss four weeks.

"We're hoping it's a good thing we deemed it not necessary to put him on IR," McDermott said.

McDermott said Wednesday that Johnson will not play against the Jaguars.

Status: Did not practice Thursday, Friday or Saturday; Out

Dawuane Smoot, DE, toe

Dawuane Smoot missed the first two games after injuring his toe in practice on Sept. 5.

Smoot returned to practice as a full participant Wednesday.

Status: Limited participant Thursday and Friday, full participant Saturday; will play

Javon Solomon, DE, oblique

Javon Solomon has not played in 2024.

Smoot returned to practice as a full participant Wednesday.

Status: Limited participant Thursday and Friday, full participant Saturday; will play

Casey Toohill, DE, knee

Status: Limited participant Thursday, full participant Friday and Saturday; will play

Jacksonville Jaguars injury update for Monday Night Football

Tank Bigsby, RB, shoulder

Tank Bigsby took a big hit on a kickoff return by Cleveland Browns linebacker Winston Reid in the second quarter in Week 2. Bigsby lost a fumble on the play, but it was called back due to an illegal formation against the Browns.

Bigsby walked off under his own power, entered the blue medical medical tent and returned in the second half but did not play any offensive snaps.

Jaguars head coach Doug Pederson said Thursday that Bigsby is "doing well" and "on track to play."

Status: Limited participant Thursday, Friday and Saturday; questionable

Evan Engram, TE, hamstring

Evan Engram suffered a hamstring injury in pregame warmups in Week 2 and did not play. Engram's injury occured just before Jacksonville submitted its inactive list, leaving the team with two tight ends against the Browns.

Jaguars head coach Doug Pederson said it's a "week-to-week" injury, putting Engram's availability against the Bills in doubt.

“It was significant enough to keep him out, hold him out of the football game yesterday,” Pederson said Monday. “We’ll see where he is this week. Optimistic but we’ve just got to see. Hamstrings can be funny. So, it’s kind of a week-to-week deal right now with him.”

NFL Network reporter Ian Rapaport reported Thursday that Engram's status is "very much up in the air" for Monday Night Football.

Status: Did not practice Thursday, Friday or Saturday; out

It's been a slow start for Engram, who had one catch for 5 yards in Week 1. He's coming off a career year, leading all NFL tight ends with 114 receptions and finishing with 963 receiving yards in 2023.

Tyler Lacy, DT, toe

Tyler Lacy was inactive with a toe injury in Week 2.

Darnell Savage, DB, quad

Starting safety Darnell Savage was placed on injured reserve after hurting his quadriceps in practice on Sept. 12.

Jacksonville head coach Doug Pederson said Savage would work back into practice Thursday and "hopefully he's available" against the Bills.

Status: Limited participant Thursday, Friday and Saturday; questionable

Tyson Campbell, CB, hamstring

Starting cornerback Tyson Campbell was placed on injured reserve after hurting his hamstring in Week 1.

Status: Out

This article originally appeared on Rochester Democrat and Chronicle: Bills vs. Jaguars injury update: Evan Engram, Darnell Savage inactive