Buffalo Bills linebacker Matt Milano is out for most of the season with a torn bicep, Bills coach Sean McDermott confirmed Thursday. ESPN's Adam Schefter reported the news earlier in the day.

Milano left practice on Tuesday early with an apparent injury, just two months after he was cleared to practice again following a leg injury last season. Per Schefter, Milano, 29, will undergo surgery and will try to return later this year, possibly as soon as December.

McDermott confirmed Milano's injury in a news conference on Thursday, calling the injury an "unfortunate situation" and saying that the team was behind him. McDermott said that the team believes Milano suffered the injury during a tackling drill.

"Matt's a strong young man. I know he's going to handle this," McDermott said. "He's resilient, we've gotta be resilient. We've gotta move forward and be focused on solutions."

Milano, who has been with the Bills since 2017 and who was All-Pro in 2022, missed most of the 2023 season after fracturing his leg in Week 5. Prior to the injury, he had 30 tackles and was on track for another standout season.

It's a tough blow to the Bills as injuries pile up on the defensive end. Safeties Mike Edwards (hamstring) and Cole Bishop (shoulder) are both week-to-week after suffering injuries during practice, and defensive tackle Ed Oliver left last Saturday's preseason opener with a knee injury, although he has since returned to camp.