Los Angeles Rams receiver Cooper Kupp is expected to miss "an extended period of time" with an ankle injury and could go on injured reserve, according to head coach Sean McVay.

Kupp suffered the injury during Week 2's 41–10 loss to the Arizona Cardinals. During the first quarter, his left ankle was rolled while being tackled. He was helped off the field, but walked to the locker room without assistance — albeit with a noticeable limp.

Following the game, Kupp was seen wearing a walking boot on his left leg as he left the locker room.

Prior to leaving the game, Kupp had four receptions for 37 yards. In Week 1's loss to the Detroit Lions, he caught 14 passes for 110 yards and one touchdown.

Kupp's injury leaves the Rams without their top two receivers. Puka Nacua is expected to be out 5-7 weeks after sustaining a sprained PCL in his right knee against Detroit and being placed on injured reserve.

Cooper Kupp

WR - LAR - #10

2024 - 2025 season

382

Yds

76.4

Y/G

56

Targets

41

Rec

2

TD

With Kupp and Nacua out, Demarcus Robinson and Tyler Johnson take over as the Rams' top receivers. Robinson has six catches for 11 yards this season, while Johnson has seven receptions for 99 yards.

This will be the third consecutive season during which Kupp has missed time due to injury. Last season, he missed the first four games of the season because of a strained hamstring. In 2022, Kupp suffered a sprained ankle that limited him to nine games.

When healthy and able to play all 17 games in 2021, Kupp had a spectacular campaign in which he led the NFL with 145 receptions, 1,947 yards and 16 touchdowns.

The Rams (0–2) host the San Francisco 49ers (1–1) in Week 3 on Sunday at 4:25 p.m. ET.