The Detroit Lions and San Francisco 49ers play on Sunday, Jan. 28 at Levi's Stadium in a game on the NFL Playoffs schedule for the conference championship weekend.

Which team will win the NFC Championship Game?

Check out these NFL Playoffs picks and predictions for the game, which can be seen at  4:30 p.m. MST on FOX and FOX Deportes (stream with free trial from FUBO).

The 49ers are a 6.5-point favorite over the Lions in NFL Playoffs odds for the NFC title game, courtesy of BetMGM Sportsbook.

San Francisco is -300 on the moneyline, while Detroit is +240.

The over/under (point total) is set at 51 points.

The Lions are coming off a 31-23 win against the Tampa Bay Buccaneers in their NFL Divisional Round game. The 49ers are coming off a 24-21 win against the Green Bay Packers. They did not play each other in the regular season.

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The Arizona Republic: 49ers 27, Lions 23

Jeremy Cluff writes: "Can the Lions beat the 49ers? Yes, they can. Will they? We don't think so. Detroit will have to play outside the friendly confines of Ford Field for the first time this postseason and San Francisco's defense will get to Jared Goff enough to force some turnovers. Brock Purdy will be efficient enough to lead the 49ers back to the Super Bowl for the first time since 2020."

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Sporting News: 49ers 31, Lions 28

Bill Bender writes: "The Lions are the best team against the spread this season at 13-6. Detroit is 2-1 ATS and 1-2 S/U as an underdog this season, and those games were against the Chiefs, Cowboys, and Ravens. San Francisco is 4-0 ATS and 4-0 S/U when favored by four points or less. This should be a classic -- and Samuel’s status is huge -- but we’ll stick with the home team."

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CBS Sports: 49ers 27, Lions 23

Cody Benjamin writes: "Detroit is a feel-good story, living up to preseason hype as a hard-nosed fighter, and if Goff gets run support while feeding St. Brown early and often, the Lions are capable of the upset. But Goff has also been significantly less effective on the road than at home, and the 49ers tend to take advantage of defensive opportunities. While Purdy and Shanahan proved vulnerable in their decision-making against the Packers, the superior talent is the safer bet."

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Sports Betting Dime: 49ers 29.9, Lions 19.9

The site's formula predicts that the 49ers will win the NFL Playoffs game against the Lions.

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ESPN: 49ers have a 74.1% chance to beat Lions

The site gives the Lions a 25.9% shot at winning the NFC Championship Game.

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Bookies.com: Bet the Lions with the points vs. 49ers

Bill Speros writes: "Winning an NFC title game on the road is nothing new for Lions QB Jared Goff. He did it 5 years ago with the Rams, with some help from the refs. He’s been slinging it of late. Dan Campbell’s Lions have the best record in the NFL against the spread both this season – at 13-6 – and overall since Campbell took over the Lions before the 2021 season – 36-17. They are roaring on offense and defense. This is their year - until it isn't."

STREAM THE GAME: Watch NFC Championship Game live with FUBO (free trial)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Detroit Lions at San Francisco 49ers picks, odds for NFL Playoffs game