Week 6 of the 2024 NFL season starts on "Thursday Night Football" with a massive NFC West clash when the San Francisco 49ers (2-3) travel to take on the Seattle Seahawks (3-2).

Each side is coming off a disappointing loss in Week 5 and will be eager to get back in the win column during prime time at Lumen Field in Seattle, Washington. Both teams were favored by 7 points at home and were upset on Sunday.

The Seahawks have dropped two consecutive games after an impressive 3-0 start to the season under first-year head coach Mike Macdonald. Seattle was upset 29-20 by the New York Giants in Week 5.

The defending NFC champion 49ers are coming off a 24-23 loss at home against the Arizona Cardinals. It's been a tumultuous start to the season for San Francisco. Running back Christian McCaffrey remains sidelined. The 49ers have a Super Bowl rematch up next with the Kansas City Chiefs in Week 7, but they can't afford to overlook their division rivals on Thursday night.

Entering Week 6, both teams rank inside the top ten in total offense (SF 2nd, 407.4 YDS/G) and (SEA 7th, 376.2 YDS/G). There is plenty of star power on both rosters, which adds to the excitement of this matchup.

Here's everything you need to know for Week 6's "Thursday Night Football" matchup between the Seahawks and 49ers.

Seahawks vs. 49ers start time

• Date: Thursday, October 10, 2024

• Time: 8:15 p.m. ET

The Seahawks and 49ers game will kick off Week 6 of the 2024 NFL season with "Thursday Night Football" at 8:15 p.m. ET.

Seahawks vs. 49ers TV Channel

• Live stream: Amazon Prime Video

"Thursday Night Football" will exclusively stream on Amazon Prime Video.

Watch "Thursday Night Football" with a Prime Video subscription

Seahawks vs. 49ers predictions, picks

Here are the USA TODAY Sports staff’s predictions for the “Thursday Night Football” Week 6 matchup:

• Lorenzo Reyes: 49ers 25, Seahawks 17

• Tyler Dragon: 49ers 25, Seahawks 20

• Jordan Mendoza: 49ers 26, Seahawks 20

Seahawks vs. 49ers odds, moneyline, over/under 

The 49ers are favorites to defeat the Seahawks in Week 6, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024, including the ESPN BET app and Fanatics Sportsbook promo code.

• Spread: 49ers (-3.5)

• Moneyline: 49ers (-190); Seahawks (+155)

• Over/under: 47.5

Not interested in this game? Our guide to NFL betting odds, picks, and spreads has you covered with "Sunday Night Football" odds and "Monday Night Football" odds.

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This article originally appeared on USA TODAY: Seahawks vs. 49ers live updates: Predictions, how to watch 'TNF'