The 2023 NFL season kicks off with a number of intriguing matchups.

First, the defending Super Bowl champion Kansas City Chiefs host the upstart Detroit Lions in the NFL Kickoff Game. The Buffalo Bills' win over the Los Angeles Rams in the 2022 NFL Kickoff Game marked just the fifth time since 2002 that the home team lost in the Thursday night season opener.

Week 1 will also feature the debuts for three first-round quarterbacks. No. 1 overall pick Bryce Young of the Carolina Panthers hits the road to face the Atlanta Falcons. No. 2 overall pick C.J. Stroud faces a possible Super Bowl contender when the Houston Texans visit the Baltimore Ravens. No. 4 overall pick Anthony Richardson and the Indianapolis Colts host the Jacksonville Jaguars.

The opening weekend concludes with future Pro Football Hall of Fame quarterback Aaron Rodgers' debut with the New York Jets, who host the Bills in a big early season AFC East showdown.

CHARTING ALL THE GAMES: 2023 NFL schedule spreads to record 350 hours of TV

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All times Eastern.

Thursday, Sept. 7

Detroit Lions 21, Kansas City Chiefs 20

Sunday, Sept. 10

Atlanta Falcons 24, Carolina Panthers 10

Baltimore Ravens 25, Houston Texans 9

Cleveland Browns 24, Cincinnati Bengals 3

Jacksonville Jaguars 31, Indianapolis Colts 21

Tampa Bay Buccaneers 20, Minnesota Vikings 17

New Orleans Saints 16, Tennessee Titans 15

San Francisco 49ers 30, Pittsburgh Steelers 7

Washington Commanders 20, Arizona Cardinals 16

Green Bay Packers 38, Chicago Bears 20

Las Vegas Raiders 17, Denver Broncos 16

Miami Dolphins 36, Los Angeles Chargers 34

Philadelphia Eagles 25, New England Patriots 20

Los Angeles Rams 30, Seattle Seahawks 13

Dallas Cowboys 40, New York Giants 0

Monday, Sept. 11

New York Jets 22, Buffalo Bills 16 (OT)

This article originally appeared on USA TODAY: NFL Week 1 schedule 2023: Dates, time, TV info