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Are there any perfect brackets left in March Madness? Nope. Upsets knock everyone out.

The second full day of March Madness brought even more upsets, busting brackets for everyone in the world.

ESPN said no perfect brackets remained on its site with the first round of the men's NCAA Tournament completed. That's 0 perfect brackets out of 22,114,647 entries.

The NCAA says there are no unblemished brackets remaining in its own game, CBS' or Yahoo's.

Though there were few perfect brackets left entering the Friday afternoon slate, the number dwindled even further when No. 13 Yale knocked off No. 4 Auburn. Nearly simultaneously, No. 10 Colorado won a thriller, 102-100, against No. 7 Florida. Later in the night, a pair of No. 12 seeds — James Madison and Grand Canyon — helped to eliminate the small number of people still standing.

Eight double-digit seeds advanced to the second round of the NCAA Tournament, probably the main reason everyone's bracket is in shambles.

There's a reason they call it March Madness. And there's a reason there's never been a perfect bracket before.

This article originally appeared on USA TODAY: March Madness perfect bracket: How many men's brackets have no losses?