The Kansas City Chiefs and Buffalo Bills play on Sunday, Jan. 21 at Highmark Stadium in a game on the NFL Playoffs schedule for the Divisional Round weekend.

Which team will win the second-round NFL postseason game?

Check out these NFL Playoffs picks and predictions for the game, which can be seen at  4:30 p.m. MST on CBS and Paramount+.

The Bills are a 2.5-point favorite over the Chiefs in NFL Playoffs odds for the game, courtesy of BetMGM Sportsbook.

Buffalo is -145 on the moneyline, while Kansas City is +120.

The over/under (point total) is set at 45.5 points.

The Chiefs are coming off a 26-7 win against the Miami Dolphins in their NFL Wild Card game. They finished the regular season with an 11-6 record and are the No. 3 seed in the AFC playoffs.

The Bills are coming off a 31-17 win against the Pittsburgh Steelers. They went 11-6 and are the No. 2 seed. The Bills beat the Chiefs in Kansas City in Week 14, 20-17.

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The Arizona Republic: Bills 24, Chiefs 23

Jeremy Cluff writes: "Is this the year that the Bills will get past the Chiefs? Buffalo won a close game against the Chiefs in Kansas City in Week 14, we predict they will win another close game against the Chiefs in Buffalo in the Divisional Round, with the Bills' defense coming up big late."

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FanSided: Take the Chiefs to beat the Bills in AFC Divisional Round

Joe Summers writes: "Buffalo has looked excellent the last two months, rising from a 6-6 start to secure the No. 2 seed in the AFC. The Bills beat the Chiefs earlier this season, though Kansas City was without Isiah Pacheco and Drue Tranquill, two of the most important players on the roster. Of course, the Chiefs were one Kadarius Toney offsides penalty away from a victory, and I've got confidence in Mahomes as an underdog. If you prefer a bet on the total, the under is 5-2 in the Chiefs' last seven games as underdogs and this looks like the league's best defense. It'll be a fun one, but I'm backing Kansas City to come out on top."

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CapperTek.com: Bills 21, Chiefs17

It writes: "In their last 10 games, the Bills have a Straight Up record of 7 wins, 3 losses and an active Straight Up streak of 6 wins in a row. Also in their last 10 games, the Bills have an Against-the-Spread record of 5 wins, 4 losses, 1 push and an active Against-the-Spread streak of 2 wins in a row. The Game Total Points results for Bills games have a record of 4 overs, 6 unders in their last 10 games with an active streak of 1 over in a row."

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Stats Insider: Chiefs 23, Bills 21

The site is giving the Chiefs a 58% chance to win the game and the Bills a 42% chance to advance to the AFC Championship Game.

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Bookies.com: Bet the Chiefs with the points vs. Bills on Sunday

Bill Speros writes: "Buffalo dominated Pittsburgh Monday 31-17 at home in a game that was delayed a day by a snowstorm. The Chiefs froze out the Dolphins in Kansas City on Saturday. A two-day disparity in time off might be an issue here in terms of getting players fully healed. One would imagine Andy Reid’s been game-planning for the Bills in the postseason since last year. This is the first time QB Patrick Mahomes will be playing an AFC playoff game on the road. Both teams are used to the cold. There won’t be any blizzards this weekend in Orchard Park. The Swifties have been winning all season with its defense. The Bills have shown themselves to be content with running the ball and controlling clock. The Chiefs cover on the road – having done so 9 straight times against AFC opponents. And they’ve won their past four games outright as underdogs. We’d lean on the under, but not at this number. Perhaps 13 seconds will be a bit shorter in New York."

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Kansas City Chiefs at Buffalo Bills picks, odds for NFL Playoffs game