The Jaguars will be without Trevor Lawrence again in Week 11, as Jacksonville head coach Doug Pederson ruled the starting quarterback out against the Detroit Lions before practice on Wednesday.

Lawrence also missed Jacksonville's Week 10 loss to the Minnesota Vikings, after a week of limited practice participation due to a left shoulder injury suffered against the Philadelphia Eagles in Week 9.

"Trevor will be out, we decided this week," Pederson told reporters Wednesday. "He's getting close, but to make sure that — again, you guys know how I am with injuries, we don't want to put a player out there that's not 100%. So, we're going to rest him one more week."

Lawrence is reportedly nursing a "significant" AC joint sprain in his non-throwing shoulder.

Lawrence has completed 168-of-274 (61.3%) passes for 2,004 yards with 11 touchdowns and six interceptions in nine starts this season. He has also rushed for three touchdowns.

Pederson acknowledged the benefit of Jacksonville's bye week following the Jaguars' matchup with the Lions, effectively giving Lawrence a three-week recovery window given his light workload in practice last week.

That said, Pederson did not guarantee Lawrence would be ready to go come the Jaguars' Week 13 home bout with the Houston Texans.

"It's still a question mark. But, you know, I'm optimistic," Pederson said.

Jacksonville native Mac Jones will start against the Lions, in Lawrence's place for the second consecutive week. The Jaguars' backup quarterback completed 14-of-22 passes for 111 yards with two interceptions and a fumble against the Vikings.

This article originally appeared on Jaguars Wire: Jaguars QB Trevor Lawrence ruled out vs. Lions