It’s Drew Pyne’s game.

Missouri football starting quarterback Brady Cook has been ruled out of the Tigers’ game against Oklahoma on Saturday on the night before the reunion between the old Big Eight and Big 12 rivals in Columbia. Cook was listed with an “out” designation on Missouri’s Friday evening availability report.

The quarterback had been listed as “questionable” on each of the Tigers’ Wednesday and Thursday reports. Now, the quarterback will not start for Mizzou for the first time since a Nov. 26, 2021, game at Arkansas, ending a 35-game streak.

All SEC teams are required to release reports each night in the three days leading up to an in-conference matchup and one final report 90 minutes before the game kicks off.

The possible designations, from most likely to play to least likely, are as follows: available; probable; questionable; doubtful; out.

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The quarterback followed almost the opposite trajectory to his week leading up to MU’s game against Alabama. He began that game week with a doubtful designation on the Wednesday report but was upgraded to questionable on the Thursday and Friday lists.

Cook was then listed as a game-time decision, but he ended up starting the game in Tuscaloosa with what was ruled a high-ankle sprain and played until the midpoint of the second quarter, when a separate injury to his hand/wrist area ended his day.

Mizzou will release one more report before facing Oklahoma, which will be published approximately 90 minutes before the 6:45 p.m. kickoff. That means the report should be expected at approximately 5:15 p.m. Saturday. Cook’s status cannot change, as listing a player as “out” is an official designation.

That means the offense is turning over to Pyne.

In two relief appearances against Auburn and Alabama, Pyne has led one scoring drive for a field goal in 13 total possessions that he started the drive. Missouri has turned the ball over five times in that span with Pyne in the game, with one fumble, one turnover on downs and three intercepted passes.

Elsewhere on Missouri’s Friday availability report, starting running back Nate Noel was listed as probable, meaning he is likely to return to the field. Starting wide receiver Mookie Cooper was downgraded as out; starting left guard Cayden Green remained probable; and backup linebacker Brayshawn Littlejohn is officially ruled out.

This article originally appeared on Columbia Daily Tribune: Brady Cook Friday injury update: Missouri football quarterback out vs OU